tag:blogger.com,1999:blog-7857054149675424609.post1733363794911373211..comments2024-02-24T08:58:08.581+00:00Comments on RNAi Therapeutics: CALAA-01 Results Indicate RNAi Therapeutics to Revolutionize Solid Cancer TreatmentDirk Hausseckerhttp://www.blogger.com/profile/18320439857875629714noreply@blogger.comBlogger6125tag:blogger.com,1999:blog-7857054149675424609.post-53454748735510642322010-08-16T20:05:28.276+00:002010-08-16T20:05:28.276+00:00Hi Dirk,
We are showing promising results using n...Hi Dirk,<br /><br />We are showing promising results using nanoparticles to deliver siRNA to tumors via intravenous injection in mice and rats. Hopefully, these techniques will continue to yield increasing efficacy in humans.Neuromicshttps://www.blogger.com/profile/08144200376477478451noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-79798046660388183822010-03-30T19:55:17.095+00:002010-03-30T19:55:17.095+00:00Guy,
I believe a year from now will be a good tim...Guy,<br /><br />I believe a year from now will be a good time for such a review as I am still looking for important data from Alnylam’s VSP and TTR and Tekmira’s ApoB2. Silence and Calando may also have interesting updates from their cancer trials.Dirk Hausseckerhttps://www.blogger.com/profile/18320439857875629714noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-20854654644900546592010-03-30T17:53:20.987+00:002010-03-30T17:53:20.987+00:00Thanks for your clarification, Dirk. I think I und...Thanks for your clarification, Dirk. I think I understand what you were trying to say about "highly encouraging" (that, at least, there wasn't extreme toxicity and that there was consistency between microscopy and RACE for each of the 3 patients, even if the consistency was a negative result).<br /><br />In terms of "RNAi mechanism of action for the first experience of RONDEL Unknownhttps://www.blogger.com/profile/05205285919732112713noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-83524507220262528332010-03-29T18:21:08.866+00:002010-03-29T18:21:08.866+00:00Hi Dirk,
Do you have an update on the clinical tr...Hi Dirk,<br /><br />Do you have an update on the clinical trials of siRNAs from different companies? (Phases, timelines, etc.) Just curious where the technology is at.<br /><br />Guy.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-74003765138829846782010-03-28T17:20:55.103+00:002010-03-28T17:20:55.103+00:00Hi Nick-
your point about the limited number of p...Hi Nick- <br />your point about the limited number of patients and the need for more is well taken. On the other hand, I believe the imaging data are consistent with the dose-dependent RNAi mechanism of action (5' RACE results). Beyond the qualitative data, it would be interesting to know how much of injected amount of RONDEL actually made it intact into the solid tumors and, related to Dirk Hausseckerhttps://www.blogger.com/profile/18320439857875629714noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-46855231952655394072010-03-26T17:10:01.208+00:002010-03-26T17:10:01.208+00:00Hi Dirk,
Thanks for the commentary. What do you th...Hi Dirk,<br />Thanks for the commentary. What do you think: the fact that only 1.5 of the patients (patient C, and a little bit of patient B) showed CDP update by fluorescent imaging, only one of the 3 patients (patient C only) showed intended mRNA cleavage by RACE, and the TEM lacked some negative controls.....<br />As much as I personally want siRNA therapeutics to succeed, I might be a little Unknownhttps://www.blogger.com/profile/05205285919732112713noreply@blogger.com