tag:blogger.com,1999:blog-7857054149675424609.post1734012892567608197..comments2024-02-24T08:58:08.581+00:00Comments on RNAi Therapeutics: ALN-RSV01 Update: The Drug is Safe- and Efficacious?Dirk Hausseckerhttp://www.blogger.com/profile/18320439857875629714noreply@blogger.comBlogger5125tag:blogger.com,1999:blog-7857054149675424609.post-39865990745403164942009-11-25T14:04:38.698+00:002009-11-25T14:04:38.698+00:00Thanks a lot for fingering the the trials from Qua...Thanks a lot for fingering the the trials from Quark. The World of RNi therapeutics is really useful. By the way do you have any update on AGN211745 from Allergen, which was in Phase II (Ref: Nature Reviews Drug Discovery 2009, 8, 525-526). The clinicaltrials.gov says the trials have been terminated. Is it true?pradeepkumar pihttps://www.blogger.com/profile/00288528678251357568noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-59182912395972653372009-11-24T17:41:34.571+00:002009-11-24T17:41:34.571+00:00To my knowledge, there is not any single place whe...To my knowledge, there is not any single place where you can find such information. The 'World of RNAi Therapeutics' map may give you a start on compiling such a list. Quark Pharmaceuticals I believe has 3 ongoing phase II trials that involve modified siRNAs (AtuRNAs with 2'-O-methyl at every second base). So yes, there is precedence for this.Dirk Hausseckerhttps://www.blogger.com/profile/18320439857875629714noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-1556679663913723192009-11-24T16:40:30.019+00:002009-11-24T16:40:30.019+00:00Dear Dirk, Thanks a lot for this information. I wa...Dear Dirk, Thanks a lot for this information. I was always thinking ALN-RSV01 is a a chemically modified one since its from Alnylam. By the way do you have info about any chemically modified siRNAs in Phase II or Phase II of clinical trials? Is there any place/article, I can get info on siRNAs which are in mid or advanced clinical trails? Clinicaltrials.gov doesnt provide all the info which we pradeepkumar pihttps://www.blogger.com/profile/00288528678251357568noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-90185106684879078642009-11-24T16:29:17.681+00:002009-11-24T16:29:17.681+00:00ALN-RSV01 is described in Alvarez et al. Antimicro...ALN-RSV01 is described in Alvarez et al. Antimicrob Agents Chemother. 2009 Sep;53(9):3952-62. <br /><br />It is an unmodified 19bp siRNA duplex with 2nt 3' overhangs. The sequence is as follows (sense strand): <br />ggcucuuagcaaagucaagdTdTDirk Hausseckerhttps://www.blogger.com/profile/18320439857875629714noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-38596770123060328372009-11-24T09:59:04.364+00:002009-11-24T09:59:04.364+00:00Is the chemical composition of ALN-RSV01 is availa...Is the chemical composition of ALN-RSV01 is available in public domain? I am interested to know what are the chemical modifications employed in this siRNA drug.pradeepkumar pihttps://www.blogger.com/profile/00288528678251357568noreply@blogger.com