tag:blogger.com,1999:blog-7857054149675424609.post1865909919239566561..comments2024-02-24T08:58:08.581+00:00Comments on RNAi Therapeutics: Recognizing and Addressing Critical RNAi Off-targeting IssueDirk Hausseckerhttp://www.blogger.com/profile/18320439857875629714noreply@blogger.comBlogger1125tag:blogger.com,1999:blog-7857054149675424609.post-11934728321022806812018-03-14T11:17:35.610+01:002018-03-14T11:17:35.610+01:00Hi Dirk, great post on siRNA off-targets with rele...Hi Dirk, great post on siRNA off-targets with relevance to RNAi therapeutics. We have looked into this extensively as well to figure out ways to reduce off-targeting. Chemical modification though working to some extent for sites with weak seed-pairing energy is still insufficient for sites with stronger seed-pairing energies. Furthermore, intra-class correlation (i.e. correlation between Anonymoushttps://www.blogger.com/profile/15811079424817671299noreply@blogger.com