tag:blogger.com,1999:blog-7857054149675424609.post314995155188089619..comments2024-02-24T08:58:08.581+00:00Comments on RNAi Therapeutics: Time is running out for BenitecDirk Hausseckerhttp://www.blogger.com/profile/18320439857875629714noreply@blogger.comBlogger30125tag:blogger.com,1999:blog-7857054149675424609.post-53191213133359218962015-07-09T08:29:59.254+00:002015-07-09T08:29:59.254+00:00What is this company?!!
In the beginning it was ...What is this company?!! <br /><br />In the beginning it was a HIV cure all. Then it was in to different things including hair loss. Only to end up as the Holy Grail for HCV when they bought back their own program from Tacere. Now that seems to be superceded by the same stunt for HBV! <br /><br />They are buying back their own JV program from the Chinese outfit Bionomics!<br /><br />This isn'tAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-24551022031438435562015-05-31T22:13:13.714+00:002015-05-31T22:13:13.714+00:00A difficult path it is. But please, be patient you...A difficult path it is. But please, be patient you say, you must be kidding. A publicly listed company for between fifteen and twenty years. Tens of millions of dollars. An equal amount of wealth destruction while personnel are grotesquely and hypocritically enriched. The best and the brightest brains working tirelessly for those years and all you can say is be patient! <br /><br />Get lost is Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-23605911211423544192015-05-28T15:58:04.530+00:002015-05-28T15:58:04.530+00:00If the HEP C program works , excellent , but Benit...If the HEP C program works , excellent , but Benitec is a platform company with its technology being used by a number of other player. The Tacere Hep C program as a first of kind gene therapy dosing was deliberately conservative , hence can be increased on further review . Please be patient new cures are a difficult path to follow.GENE genienoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-47461226697468732892015-05-22T16:08:04.540+00:002015-05-22T16:08:04.540+00:00OBLITERATE HCV in one shot. I have nothing to comp...OBLITERATE HCV in one shot. I have nothing to compare.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-87612740253893136492015-05-22T16:02:28.127+00:002015-05-22T16:02:28.127+00:00let me help . . . we are using a shotgun (tt034) t...let me help . . . we are using a shotgun (tt034) that is clearly targeted on a large dartboard. HCV is only present in a few of the sections (cells) on the board (liver). cohort 1 is a 1 percent dose. when "shot" from the gun, it will hit 1 percent of the whole target. the virus may not be in any of the cells "hit" by the first shot. now, when we get to cohort 5, using a 100 Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-84741025234208810012015-05-12T20:07:47.376+00:002015-05-12T20:07:47.376+00:00Dirk:
Will #Moderna's spin-outs each develop t...Dirk:<br />Will #Moderna's spin-outs each develop their own delivery from scratch? How does 'de-centralization' make sense in light of 'delivery'?<br /><br />No. Would expect the structure to like a pearl necklace. Each pearl demonstrating its own beauty while being tied to a greater whole by a invisible thread. As long as proper structures and channels exist for the invisibleAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-47530357799449242192015-05-04T18:19:07.662+00:002015-05-04T18:19:07.662+00:00When comparing, it is best to compare like with li...When comparing, it is best to compare like with like. In that case, we are better to compare BLT's NASDAQ listing ambitions with those of ACL: it got pulled the day of expected listing.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-74411550678227107122015-05-04T10:20:48.644+00:002015-05-04T10:20:48.644+00:00Just to put things into some perspective I'll ...Just to put things into some perspective I'll make a little comparison. Genetix Pharmaceuticals (renamed Bluebird Bio) raised $12m in 2003 to fund their PI/II for sickle cell and thalassemia major. The first patients were enrolled in 2015 and 2014 respectively. Benitec first dosed 3 patients in 2007 for HIV and only re-acquired the HCV program in Oct 2012 and have now dosed 5 patients. I Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-71556658529666958452015-05-02T03:26:24.026+00:002015-05-02T03:26:24.026+00:00Twenty years of just a little bit more and then it...Twenty years of just a little bit more and then it will all be right. Twenty years work to get a total of four patients dosed with no viral knockdown. Say what you like about them but don't say they are not dogged and determined. But its as if someone else has to come in and tell them what the situation really is. <br /><br />That the probability of the next thing making it a success are Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-78902214326936275562015-04-27T16:36:03.502+00:002015-04-27T16:36:03.502+00:00Roche doing deals with 4D for viral vector deliver...Roche doing deals with 4D for viral vector delivery of gene therapy?<br /><br />That Benitec mob must be on to something good if Roche are following their lead.<br /><br />Cohort four will get the response and the knockers will eat crow. More improvements to come from doggybone and 4D for ddRNAi. Some people just don't get it.<br />Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-38314244005735522752015-04-20T04:49:33.628+00:002015-04-20T04:49:33.628+00:00Dirk, The first tt034 cohort was 1 percent of coho...Dirk, The first tt034 cohort was 1 percent of cohort 5 dose. You know the "magic" of tt034 is the continued production of SHRNA in the cells cytoplasm. Dose does not need a high multiple because it will continue to be produced in the cell. I think that is what many people are missing about ddrnaiAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-65427209649472209432015-04-19T15:22:29.079+00:002015-04-19T15:22:29.079+00:00Anonymous said, "And how are those people fee...Anonymous said, "And how are those people feeling right now who invested in Arrowhead back in Sep/Oct last year when Dirk was spruiking their technology?"<br /><br />By any reasonable analysis, Dirk deserves high marks for his calls on ARWR (and many other RNAi stocks). Your cherry picking of the Sep/Oct 2014 time frame is either the result of ignorance of the larger picture or a Newsurferhttps://www.blogger.com/profile/05446361338587051489noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-57726660426548983612015-04-19T04:28:51.274+00:002015-04-19T04:28:51.274+00:00Yes. We are allowed to talk about Merck. The contr...Yes. We are allowed to talk about Merck. The contract however, stipulates we are not allowed to talk about the other one. Isn't that right Dirk?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-6353473043159280872015-04-18T07:53:11.246+00:002015-04-18T07:53:11.246+00:00The Merck with Moderna photo says it all.
Who is...The Merck with Moderna photo says it all. <br /><br />Who is going to get into the flea ridden bed of ALNY to develop RGLS technology?<br /><br />Seems to me there is still a large piece of the jig-saw puzzle missing.PfizerSlothnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-87160384686848013852015-04-12T05:44:59.627+00:002015-04-12T05:44:59.627+00:00That's the problem with those who have a sense...That's the problem with those who have a sense of self importance and entitlement. <br /><br />They always think they are so much better than everyone else they can talk down to them as if they are idiots for they are the great unwashed.<br /><br />As the great Abraham Lincoln once said, ...you can't fool all of the people all of the time.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-9620940845325751492015-04-11T01:32:23.105+00:002015-04-11T01:32:23.105+00:00Dirk is a confused transgender reject
ISIS - world...Dirk is a confused transgender reject<br />ISIS - world's most valuable stock ?<br />ALNY a fraud ?<br />RGLS a ???<br />Face it folks Dirk is a paid shill<br />Carnival Huckster<br />He is now naked<br />He is totally exposed<br />and he has a small peckerENORMOOUS JOHNSONnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-18381341480170662392015-04-11T01:21:06.241+00:002015-04-11T01:21:06.241+00:00Dirk comments are a parody of sorts on trading.
F...Dirk comments are a parody of sorts on trading.<br /><br />First, he says ISIS will be the next Apple while continually beating up ALNY.<br /><br />His position on ARWR has changed so many times I don't even know what it is.<br /><br />On the next breath he says the leadership of RNAi is about to change but doesn't say how or by who. Yet still maintains his view ISIS is the bomb and will Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-67695338134318092342015-04-09T02:37:46.301+00:002015-04-09T02:37:46.301+00:00"everyone is entitle to change his mind, howe..."everyone is entitle to change his mind, however, usually Dirk is right about what is going to happen, taking just the Kynmaro example is very low and stupid in my opinion....<br />someone is involved with Benitec I am afraid...."<br /><br />And how are those people feeling right now who invested in Arrowhead back in Sep/Oct last year when Dirk was spruiking their technology?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-25852145525782558462015-04-09T01:40:40.308+00:002015-04-09T01:40:40.308+00:00You were down on Novogen a while back. You missed ...You were down on Novogen a while back. You missed that spike then and now look at them again today.<br /><br />Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-54392663609404067062015-04-08T19:00:05.985+00:002015-04-08T19:00:05.985+00:00Dirk,
For a frog in a bucket, the world is just o...Dirk,<br /><br />For a frog in a bucket, the world is just one bucket big...Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-65548337735901475042015-04-08T18:43:42.469+00:002015-04-08T18:43:42.469+00:00Drick,
RXII NEWS - http://immuno-oncologynews.co...Drick, <br /><br />RXII NEWS - http://immuno-oncologynews.com/2015/04/07/rxi-pharmaceuticals-and-mirimmune-llc-ink-exclusive-sd-rxrna-cancer-immunotherapy-technology-licensing-agreement/<br /><br />Stop bashing that one too!Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-20712391419397325982015-04-08T16:14:41.487+00:002015-04-08T16:14:41.487+00:00everyone is entitle to change his mind, however, u...everyone is entitle to change his mind, however, usually Dirk is right about what is going to happen, taking just the Kynmaro example is very low and stupid in my opinion....<br />someone is involved with Benitec I am afraid....Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-11331385857134168942015-04-08T13:50:19.680+00:002015-04-08T13:50:19.680+00:00While your sentiment is understood, it serves no p...While your sentiment is understood, it serves no purpose to call him names. I would rather he was engaged in an actual debate and there is little to be gained in debating with people who resort to name calling. Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-68745021891615943792015-04-08T06:22:17.079+00:002015-04-08T06:22:17.079+00:00Dirk's comments are a really good indication t...Dirk's comments are a really good indication that Benitec will succeed, especially when compared to what he has said about ISIS.<br /><br />This is what he said about ISIS on May 23 2014.<br /><br />"I have been following ISIS Pharmaceuticals for a dozen years now and have heard Stan Crook, its CEO, promise his shareholders in as many years that profitability was just around the corner.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-76747101475519348262015-04-08T05:46:38.981+00:002015-04-08T05:46:38.981+00:00I'm not really sure what it is that you expect...I'm not really sure what it is that you expect Dirk. This is still technically in phase I, so why would anyone be expecting to hear about efficacy? Why not wait until cohort III (the beginning of Phase IIa) is at least dosed until you start suggesting that the TT-034 doesn't work. Everyone is frustrated that the dosing is taking forever, however this is hardly surprising and certainly Anonymousnoreply@blogger.com