tag:blogger.com,1999:blog-7857054149675424609.post4257259209709322883..comments2024-02-24T08:58:08.581+00:00Comments on RNAi Therapeutics: What to Expect from RNAi Therapeutics in 2013Dirk Hausseckerhttp://www.blogger.com/profile/18320439857875629714noreply@blogger.comBlogger15125tag:blogger.com,1999:blog-7857054149675424609.post-26256495684060677772013-01-04T17:59:37.059+00:002013-01-04T17:59:37.059+00:00Hello Dirk...and Happy New Year! Could you please ...Hello Dirk...and Happy New Year! Could you please comment on Solstice Biologics and there "NEW" RNA Delivery Tehnology? THANKS!Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-66994815634441080932013-01-04T15:32:29.511+00:002013-01-04T15:32:29.511+00:00Dirk,
I had a bit more of a look at this recently...Dirk,<br /><br />I had a bit more of a look at this recently awarded Fire patent. <br /><br />I don't believe this threatens Graham IP at all, as its filing date is 28 Sept 2007. Its concluding comment to overcome the Examiner's interferon response in mammalian cells says it all:<br /><br />'Collectively, the present application and the state of the art at the time of filing fully Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-25824239517214379642013-01-03T23:10:35.826+00:002013-01-03T23:10:35.826+00:00Steve...I can understand your sentiment, but let&#...Steve...I can understand your sentiment, but let's don't forget that the way Big Pharma has played RNAi Rx so far was amateur at best. To consider them bellwethers of the validity of RNAi Rx science would be a mistake. Dirk Hausseckerhttps://www.blogger.com/profile/18320439857875629714noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-14037049326536111212013-01-03T22:18:52.450+00:002013-01-03T22:18:52.450+00:00Thanks for the reference Dirk. From the Graham ...Thanks for the reference Dirk. From the Graham '099 re-exam submissions, i doubt CSIRO and Graham would have a problem in providing evidence and swearing of an earlier invention date than Fire, if required of them. Infact I think they already did, but it wasn't necessary to uphold the claims. <br /><br />I doubt Carnegie would want to push their luck in putting a blow torch, such as a Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-21945344448644751792013-01-03T18:52:00.465+00:002013-01-03T18:52:00.465+00:00<<>>
I would be much more optimistic ...<<>><br /><br />I would be much more optimistic about the field as a whole if one of the majors could get something into the clinic. In spite of Alnylam's and other small outfits best efforts, we still haven't really cured anyone. It's hard to know what's real and what is just hope.Steve_382noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-50349306823844707002013-01-03T16:03:33.044+00:002013-01-03T16:03:33.044+00:00Claim 6 of the recently issued Fire patent US 8,28...Claim 6 of the recently issued Fire patent US 8,283,329 covers ddRNAi in 'mammals':<br /><br />'6. A method of inhibiting expression of a target gene in an animal cell in a mammal comprising providing at least one ribonucleic acid (RNA) to the animal cell in an amount sufficient to inhibit the expression of a target gene, wherein said RNAis provided to the animal cell by synthesizing Dirk Hausseckerhttps://www.blogger.com/profile/18320439857875629714noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-89290202189468227122013-01-03T14:39:04.774+00:002013-01-03T14:39:04.774+00:00City of Hope trial now fully enrolled. City of Hope trial now fully enrolled. Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-847972560755754752013-01-03T14:22:17.627+00:002013-01-03T14:22:17.627+00:00looks like Gradalis have passed someone's smel...looks like Gradalis have passed someone's smell test though:<br /><br />"<br />DALLAS, Jan. 3, 2013 -- /PRNewswire/ -- Gradalis, Inc. today announced that is has closed a $24 million Series B round of financing. Gradalis will use the funding to advance its autologous vaccine platform, FANG™, through late-stage clinical trials and expand manufacturing capabilities to accommodate Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-87970598636986870092013-01-03T12:56:02.155+00:002013-01-03T12:56:02.155+00:00Dirk,
Regarding Carnegie IP, what are the patent...Dirk, <br /><br />Regarding Carnegie IP, what are the patents or patent prosecutions for you to say it's got Benitec IP under siege?<br /><br />From what I have been able to tell, it seems to be other way around. eg: Carnegie abandoned their Fire/Mello patent application with the EPO after many years, interestingly after a CSIRO paper by De Feyter (Waterhouse / Graham plant scientist Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-47816879103085955262013-01-03T11:21:41.330+00:002013-01-03T11:21:41.330+00:00Benitec...pure IP play IMO with IP under siege by ...Benitec...pure IP play IMO with IP under siege by Carnegie. Also, Graham starting to be just one of few RNAi trigger patents required to practice ddRNAi. Not having a lab is coming to bite the company. I've been saying it ad nauseam.<br /><br />Silence...share price gone up, but it has become very quiet on scientific and biz development progress at company. Not sure what's going on there.Dirk Hausseckerhttps://www.blogger.com/profile/18320439857875629714noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-66178777392740787992013-01-03T02:58:09.992+00:002013-01-03T02:58:09.992+00:00Happy New Year to you too Dirk. Great blog. Irel...Happy New Year to you too Dirk. Great blog. Ireland's Genable also planning on entering the clinic this year with it's ddRNAi/gene replacement candidate for retinitis pigmentosa. Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-19069771276626082542013-01-03T01:37:23.227+00:002013-01-03T01:37:23.227+00:00City oh Hope's HIV gene therapy trial, which i...City oh Hope's HIV gene therapy trial, which includes a ddRNAi construct, is already 'dosing' patients in its second phase. This study phase using much higher transfected cell numbers than the safety study already completed. Interim data can be expected this year. Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-24441097160524365572013-01-03T00:41:59.699+00:002013-01-03T00:41:59.699+00:00In 2013 Gradalis will complete data collection for...In 2013 Gradalis will complete data collection for a number of its clinical trials including Pll data for melanoma and ovarian cancer. I would have thought a possible cure for cancer would be worth a mention?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-76985718763542049852013-01-02T23:53:12.681+00:002013-01-02T23:53:12.681+00:00Nothing in for Silence Therapeutics
with their AT...Nothing in for Silence Therapeutics <br />with their ATU027 trial this year?? Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-55608142455890248242013-01-02T23:35:12.616+00:002013-01-02T23:35:12.616+00:00no partner for Benitec? no partner for Benitec? Anonymousnoreply@blogger.com