tag:blogger.com,1999:blog-7857054149675424609.post4716657398519585654..comments2024-02-24T08:58:08.581+00:00Comments on RNAi Therapeutics: SNALP Delivery Taking OffDirk Hausseckerhttp://www.blogger.com/profile/18320439857875629714noreply@blogger.comBlogger8125tag:blogger.com,1999:blog-7857054149675424609.post-69974804765802544922010-08-16T06:23:08.669+00:002010-08-16T06:23:08.669+00:00I have to admit that I don't know enough about...I have to admit that I don't know enough about the pharmacology of drugs administered intrathecally. ISIS believes it works for their antisense technology in neurodegenerative diseases. Alnylam, however, I believe is using direct intrastriatal infusion for their Huntington's program. If intrathecal administration can reach cells affected by SCA, then I'd think SNALP has a chance Dirk Hausseckerhttps://www.blogger.com/profile/18320439857875629714noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-43119281557206390722010-08-16T06:01:09.235+00:002010-08-16T06:01:09.235+00:00Dirk,
As the article, Alnylam/Tekmira annouces the...Dirk,<br />As the article, Alnylam/Tekmira annouces their SNALP based RNAi can reach microgram per kilo potency, I don't see any reason that SNALP can not be injected into spinocerebelar fluid, say less than 1 miligram for an adult.<br />Why you think viral based is better? Is there any reason that I don't know?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-26374631247313071932010-08-15T07:29:43.273+00:002010-08-15T07:29:43.273+00:00Warren...I'm not very familiar with the pathop...Warren...I'm not very familiar with the pathophysiology of SCA, but for HD I tend to agree that virally delivered RNAi could be very interesting.<br /><br />First commercialization of RNA Rx...I'm hopeful that the ALN-RSV01 could yield data confirming the results of the fist phase II study and that makes it approvable for the lung transplant patient population. There is not much else Dirk Hausseckerhttps://www.blogger.com/profile/18320439857875629714noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-25566556589197356972010-08-15T02:53:23.945+00:002010-08-15T02:53:23.945+00:00Dirk
When do you anticipate the first marketing o...Dirk<br /><br />When do you anticipate the first marketing of RNAI therapeutics assuming that the current clinical trials are successful.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-28424171140591742812010-08-13T07:27:31.000+00:002010-08-13T07:27:31.000+00:00Dirk
My question is do yu still think the viral ve...Dirk<br />My question is do yu still think the viral vertor is better solution for neurodegenerative diaease like Huntington or SCA ?<br />Or you have any else thinking?<br /><br />Warren YenAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-3770709827423104742010-08-11T11:56:27.297+00:002010-08-11T11:56:27.297+00:00Thanks....I have been patient with ALNY and have b...Thanks....I have been patient with ALNY and have been a TKM owner for some time. I think the Ebola results were an eye opener, but the caution exhibited by big pharma is amazing. In 2005 all biotechs could have been bought with the R&D money the top 10 drug companies spent. I have personally seen the bureaucratic nightmare in big pharma as the CSOs try to protect in-house research which in Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-54040567332757503822010-08-11T09:09:43.998+00:002010-08-11T09:09:43.998+00:00Let's discuss this in 5 months' time. A l...Let's discuss this in 5 months' time. A lot should be happening right now. Also keep in mind that the herd instinct is widespread in Big Pharma. Merck, Roche, Takeda were all linked events. I believe the Novartis decision could well force some hands this time around.Dirk Hausseckerhttps://www.blogger.com/profile/18320439857875629714noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-78298528674348773852010-08-11T00:42:21.268+00:002010-08-11T00:42:21.268+00:00Dirk
Well said....However, why is big pharma so l...Dirk<br /><br />Well said....However, why is big pharma so low to act. TKM would cost them almost nothing in terms of what their research budget is...<br /><br />Are they that dumb?Anonymousnoreply@blogger.com