tag:blogger.com,1999:blog-7857054149675424609.post5063989271685397238..comments2024-02-24T08:58:08.581+00:00Comments on RNAi Therapeutics: Extended Use of SNALP Delivery Technology Well Tolerated Dirk Hausseckerhttp://www.blogger.com/profile/18320439857875629714noreply@blogger.comBlogger5125tag:blogger.com,1999:blog-7857054149675424609.post-85172908139342992772014-10-16T17:42:44.333+00:002014-10-16T17:42:44.333+00:00Dude! This is getting ridiculous! First talking ab...Dude! This is getting ridiculous! First talking about TKM-HBV as the main value driver, crown jewel of the pipeline etc. (not just you, and no disrespect meant) and now, after the much waited pre-clin. data are out, nobody talks about it or comments on the data. Still just mongering about EBOLA. <br /><br />The press release was almost cryptic when one considers that it is their main asset.<br />Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-20426163150189827052014-10-16T15:13:24.588+00:002014-10-16T15:13:24.588+00:00No volume in TKMR and the Maxim note was completel...No volume in TKMR and the Maxim note was completely generic and uninformative; the world is waiting for your analysis of the TKM-HBV data,Dirk, at least every TKMR and RNAi investor:) Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-52574068103816819752014-10-16T14:07:26.462+00:002014-10-16T14:07:26.462+00:00... As it stands now, from my point of view, what ...... As it stands now, from my point of view, what they essentially presented yesterday is that TKM-HBV works well, at a dose that is 100% higher than the MTD dose of 3rd gen LNP Tx known today. This makes the program significantly more risky than I would've wanted. <br /><br />Or am I missing something?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-11642074957310559682014-10-16T14:03:03.197+00:002014-10-16T14:03:03.197+00:00Hi Dirk,
Any comment on the TKM-HBV data package?...Hi Dirk,<br /><br />Any comment on the TKM-HBV data package? <br /><br />The only thing I'm a bit concerned over is the level of knockdown vs. mg/kg of the Tx. Per the presentation they needed 1mg/kg to achieve ~1Log knockdown in the chimeric mouse model. They did indeed disclaim that the Chimeric mouse model might understate potency (slide 20), fine. What I find concerning is that per the Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-398550458448495452014-10-15T20:29:36.991+00:002014-10-15T20:29:36.991+00:00I believe if you check ISIS data that they do appr...I believe if you check ISIS data that they do approach 80% knockdown as well. Their shot to be given once a week and sq. And that with without excessive volume, no IV's, and no premedication required.Anonymoushttps://www.blogger.com/profile/06168686377403494357noreply@blogger.com