tag:blogger.com,1999:blog-7857054149675424609.post5092639678522149390..comments2024-02-24T08:58:08.581+00:00Comments on RNAi Therapeutics: Functional Cure of Chronic Hepatitis B: RNAi Therapeutics May Be the Only Game in Town (Part II)Dirk Hausseckerhttp://www.blogger.com/profile/18320439857875629714noreply@blogger.comBlogger12125tag:blogger.com,1999:blog-7857054149675424609.post-89258169388277400662014-09-02T17:18:55.219+00:002014-09-02T17:18:55.219+00:00There is a great list of hepatitis B treatments at...There is a great list of hepatitis B treatments at the Hepatitis Foundation's website. Here is the link: http://www.hepb.org/professionals/hbf_drug_watch.htmClark & Co.https://www.blogger.com/profile/11348079406242078667noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-36433162040709486722014-08-01T21:04:36.483+00:002014-08-01T21:04:36.483+00:00Gs96620 is just a copy of interferon..rep9ac Mabye...Gs96620 is just a copy of interferon..rep9ac Mabye need 10 yeares to exists..there no such thing as Na at this time..kuwaitAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-28224437988941736732013-06-12T06:20:40.703+00:002013-06-12T06:20:40.703+00:00there is another drug by Gilead, GS9620 and one by...there is another drug by Gilead, GS9620 and one by Replicor called Rep9AC'. Thoughts on those?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-48341528374232053702013-05-05T09:08:55.476+00:002013-05-05T09:08:55.476+00:00I am in Ghana n i need a cure for hepatitis b viru...I am in Ghana n i need a cure for hepatitis b virusDe Brownhttps://www.blogger.com/profile/12110716161314307333noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-30782343308244142372013-03-10T19:23:04.150+00:002013-03-10T19:23:04.150+00:00Myrcludex B seems to be closer to the existing nuc...Myrcludex B seems to be closer to the existing nucleoside/nucleotide inhibitors in that it mainly aims at inhibiting viral spread/amplification. ARC520 by contrast aims at an immunological functional cure. I believe it is the latter that would really constitute a breakthrough in CHB.Dirk Hausseckerhttps://www.blogger.com/profile/18320439857875629714noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-65209363591883743162013-03-10T15:58:12.013+00:002013-03-10T15:58:12.013+00:00Dirk,
You say that ARC520 should not face lots of...Dirk, <br />You say that ARC520 should not face lots of competition, but what do you think about Myrcludex B, a drug that blocks viral entry and is now in Phase I trials?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-52644373559110749902013-03-04T12:20:51.757+00:002013-03-04T12:20:51.757+00:00It is not that Roche didn't believe anymore in...It is not that Roche didn't believe anymore in RNAi. Large pharmaceutical companies, pressured by patent expirations and declining sales, no longer had the patience to follow through in the development of this novel technology.<br /><br />Roche just had to cut costs. And they wore in different fields. It is like on Wallstreet, if one guy is selling, the herd is doing the same! And most bikeriedernoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-27871803998967132032013-03-02T22:03:45.045+00:002013-03-02T22:03:45.045+00:00Looking past the immediate excitement of using RNA...Looking past the immediate excitement of using RNAi such as arrowhead's IV, the long term treatment for diseases such as this, HBV and HIV will be a gene therapy. Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-13813843658832377352013-03-02T18:11:14.714+00:002013-03-02T18:11:14.714+00:00Agreed with the first post to some extent. No one...Agreed with the first post to some extent. No one is truly unbiased. Dirk has written some nice criticism of SRPT data, which has been adored by the whole angry mob including the great Feuerstein. <br /><br />At the end of the day, read as much as one can for both bull and bear thesis, then do you own homework to make your informed decision.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-39704091591563596292013-03-02T17:38:59.193+00:002013-03-02T17:38:59.193+00:00Dirk,
It doesn't make much sense to me that A...Dirk,<br /><br />It doesn't make much sense to me that Arrowhead would advance I.V version into the clinic if they already have a more potent SubQ version of ARC520. Tekmira delayed their Ebola program just to advance more potent formulation into clinic, which makes sense.<br /><br />When they claim 99% of gene knockdown at 1 mg/kg of SubQ dose, it is not clear if it includes only SiRNA Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-34346690295713902242013-03-02T16:48:37.367+00:002013-03-02T16:48:37.367+00:00Great point, anonymous. As everyone will be quick...Great point, anonymous. As everyone will be quick to notice, Roche has never made 40 billion dollar mistakes in the past that could be indicative of the loss of future earnings...-bionoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-54127507944162321362013-03-01T18:49:02.714+00:002013-03-01T18:49:02.714+00:00You lost your credibility, sir, when you endorsed ...You lost your credibility, sir, when you endorsed Davis' work in San Antonio Spring '09- not that you were right or wrong about 'the science'- but, that you took an economic viewpoint or position. <br />Is this what you are doing now w/ regard to Arrowhead? With the same deceptive management? Can you make any objective referrals regarding either 'the science' Arrowhead Anonymousnoreply@blogger.com