tag:blogger.com,1999:blog-7857054149675424609.post5345144520640613185..comments2024-02-24T08:58:08.581+00:00Comments on RNAi Therapeutics: Tekmira Grabs Leadership Position in Messenger RNA TherapeuticsDirk Hausseckerhttp://www.blogger.com/profile/18320439857875629714noreply@blogger.comBlogger8125tag:blogger.com,1999:blog-7857054149675424609.post-14644000981275495542013-11-09T13:39:55.294+00:002013-11-09T13:39:55.294+00:00Tet, it's not much. Just meant to say that th...Tet, it's not much. Just meant to say that there was value of just learning about DPCs and then apply the lessons to GalNAcs without taking an outright license pick from Arrowhead. Dirk Hausseckerhttps://www.blogger.com/profile/18320439857875629714noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-31537635467051313972013-11-02T06:03:27.164+00:002013-11-02T06:03:27.164+00:00Dirk, sometime ago (12/13/2012)you wrote, "Al...Dirk, sometime ago (12/13/2012)you wrote, "Although GalNAc-siRNAs and DPCs are currently clearly competing, there is also scope for them to synergize, especially in the area of oligonucleotide chemistry. Curiously, Alnylam did seek access to DPCs earlier this year, supposedly for its evaluation in one of its 5x15TM programs. Learning about DPC siRNA chemistry may be of at least equal, if tettrazininoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-64520945033549008492013-10-30T21:30:11.868+00:002013-10-30T21:30:11.868+00:00Not directly, but looking at the RNAi environment ...Not directly, but looking at the RNAi environment in general. Note that MRNA is worth $5M only currently and with the right strategy it could multiply. I even believe they will have a lab before Benitec will ever have one. Of course, the investment is based on the hypothesis that Michael French will respect current shareholders when it comes to refinancing the company and setting up that lab. Dirk Hausseckerhttps://www.blogger.com/profile/18320439857875629714noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-24462326960243573492013-10-30T21:24:09.287+00:002013-10-30T21:24:09.287+00:00"accumulating some Marina Biotech on a lotter..."accumulating some Marina Biotech on a lottery ticket for a successful turnaround as investors embrace RNAi Rx again"<br /><br />With due respect Dirk, did seeing Benitec's 100% + jump in just 8 weeks influence your Marina punt?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-56544895922598391982013-10-30T19:39:19.916+00:002013-10-30T19:39:19.916+00:00No, still about 90% into ARWR! Keep a 2-year persp...No, still about 90% into ARWR! Keep a 2-year perspective on ARWR for now and you will probably do well. <br /><br />Added a few RGLS for a trade on AASLD and Kidney Week, plus accumulating some Marina Biotech on a lottery ticket for a successful turnaround as investors embrace RNAi Rx again. Dirk Hausseckerhttps://www.blogger.com/profile/18320439857875629714noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-44599685981891013812013-10-29T17:14:39.563+00:002013-10-29T17:14:39.563+00:00Dirk, your insight is appreciated. Have you put a ...Dirk, your insight is appreciated. Have you put a toe or 2 back into TKMR or still all in ARWR? just asking. Thanks friend.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-87561475837372580772013-10-29T06:44:09.304+00:002013-10-29T06:44:09.304+00:00Your questions are appropriate, but cannot be answ...Your questions are appropriate, but cannot be answered in a sentence or two. Lots of aspects to weigh, so it will largely depend on the application.Dirk Hausseckerhttps://www.blogger.com/profile/18320439857875629714noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-61057450415315364552013-10-29T03:16:22.469+00:002013-10-29T03:16:22.469+00:00I know it's early, but would you consider the ...I know it's early, but would you consider the mRNA approach the leading platform for RNA-based gene upregulation? What do think about RaNA's platform that targets lncRNA and does it without a delivery vehicle?<br />Anonymousnoreply@blogger.com