tag:blogger.com,1999:blog-7857054149675424609.post6081800767462314899..comments2024-02-24T08:58:08.581+00:00Comments on RNAi Therapeutics: RNAi Therapeutics Investors Hoping for a Merry ChristmasDirk Hausseckerhttp://www.blogger.com/profile/18320439857875629714noreply@blogger.comBlogger20125tag:blogger.com,1999:blog-7857054149675424609.post-5517861491234883712011-11-17T14:40:49.911+00:002011-11-17T14:40:49.911+00:00Rossi said today, of the CoH HIV work, one patien...Rossi said today, of the CoH HIV work, one patient now with modified gene cell markers for 3years, with 6 fold increase in the number of<br />modified stem cells. He's described the result as spectacular and opens the door for a cure.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-20742507316628808522011-11-11T06:22:29.833+00:002011-11-11T06:22:29.833+00:00It's interesting to take note: look up recent ...It's interesting to take note: look up recent rnai research on PubMed and have a look at the origin of the papers, I would say fully 50% are from China in recent times.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-67196203888497197412011-11-09T15:47:39.932+00:002011-11-09T15:47:39.932+00:00Thanks for the article. As you know, the change i...Thanks for the article. As you know, the change is already happening all around us. It won't stop at RNAi Therapeutics, and indeed has not. The knowledge-based economy is also moving more and more to the East and this should also benefit Western RNAi companies with innovative technologies to sell, especially with the paralysis elsewhere.Dirk Hausseckerhttps://www.blogger.com/profile/18320439857875629714noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-42883671712809519542011-11-09T14:15:27.480+00:002011-11-09T14:15:27.480+00:00The money would be coming from the Chinese gov. Re...The money would be coming from the Chinese gov. Read this carefully.<br />http://www.nature.com/nbt/journal/v29/n9/full/nbt0911-779b.htmlAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-9042558662719474852011-11-09T06:41:35.833+00:002011-11-09T06:41:35.833+00:00Benitec believers, honestly how much can a
Chines...Benitec believers, honestly how much can a<br /> Chinese university afford. They will come back with nothing but an. Mou.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-22334033087540883352011-11-09T05:01:01.097+00:002011-11-09T05:01:01.097+00:00And Calimmune starting their ddRNAi HIV trial next...And Calimmune starting their ddRNAi HIV trial next year. Them boys going for the cure on Berlin patient proof of concept. <br /><br />Rossi in aus next week with Benitec's chief investigators group meeting. If he likes ddrnai so do I.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-11544296852433220932011-11-09T04:51:33.814+00:002011-11-09T04:51:33.814+00:00Also the Rossi/City of Hope trial achieved proof o...Also the Rossi/City of Hope trial achieved proof of concept w ddRNAi in haemopoetic stem cell transplantation into humans with HIV with persistence for over 2 years and no safety issues. No therapeutic effect but it was designed as proof of concept/safety only.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-84928375053592815672011-11-09T04:24:31.541+00:002011-11-09T04:24:31.541+00:00What has been missed as Benitec don't run such...What has been missed as Benitec don't run such a big pr as Alny is ddrnai is already into the clinic. Gradalis are now recruiting for their PII clinical trial against melanoma using shRNA in a vaccine. That if commercialized in US is via a licence from Benitec. Expressed RNAi is via nucleus which is Benitec's Graham patent. Benitec mnmgt very busy at present - pr and sp not their priorityAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-6224692963143500262011-11-09T03:59:25.504+00:002011-11-09T03:59:25.504+00:00I don't really see why ddRNAi should be subjec...I don't really see why ddRNAi should be subject to greater regulatory hurdles than vaccines. They both stimulate the body's immune system to recognise foreign agents, destroy them, and prevent future invaders for life. They just do it in different ways. The fact that Benitec's pain therapeutic will be used on end stage cancer patients only, at least initially, should make Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-44173140171451432472011-11-09T02:11:13.464+00:002011-11-09T02:11:13.464+00:00Good that Benitec has loyal followings. 16 M mark...Good that Benitec has loyal followings. 16 M market cap is certainly not that far off from Silence's 26.7 M, perhaps one clinical trial can be started to show where the money is to the rest of the world. We still have not seen or heard anything yet. I don't know if Benitec have that much of exclusivity on ddRNAi. To say there is no delivery problem may be a bit naive. Anything Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-47037135061550083152011-11-08T23:11:50.707+00:002011-11-08T23:11:50.707+00:00If you are actually prepared to look outside the b...If you are actually prepared to look outside the box for a second, and look at what Benitec have got, instead of just writing them off, you may be very surprised. ShRNA has much greater efficiency, without the delivery problems. Sure, Benitec live from year to year with whatever funding they can get, but all RNAi companies save Alnylam are the same. Benitec have very loyal shareholders that Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-64186226236670471332011-11-08T22:39:30.495+00:002011-11-08T22:39:30.495+00:000 & 0 trade cause aus stock exchanged was clos...0 & 0 trade cause aus stock exchanged was closed. It opens during US night time.. Collab struck last week with a London group for orphan disease (MD) - they are particularly impressed with Benitec's IP. Benitec mtg with Chinese group this week re: taking a chronic pain therapeutic into clinic.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-21681261685579928712011-11-08T20:24:11.103+00:002011-11-08T20:24:11.103+00:00Right. Just looked up Benitec stock information (0...Right. Just looked up Benitec stock information (0 and 0 trade). I guess they are surviving on licensing income? Dangerous. Wonder what is their burn rate, might be sooner than 18 months without a major financing deal. With limited financing, they probably could not do much product development either. Catch-22.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-76488895426744666192011-11-08T16:04:00.518+00:002011-11-08T16:04:00.518+00:00Benitec will be bankrupt in less than 18 months. I...Benitec will be bankrupt in less than 18 months. Its all talk talk talk with those guys, they have yet to deliver anything of value.Just take a look @ there share price, you guys need to wake up and smell the coffee.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-4210558397801933112011-11-08T15:17:17.507+00:002011-11-08T15:17:17.507+00:00Yea, Dirk is actually pretty crafty with words tha...Yea, Dirk is actually pretty crafty with words than we give him credit for. Puts us in the holiday mood and gave him a sense that many out there still cares on what he writes.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-83845981180393557702011-11-08T14:16:36.884+00:002011-11-08T14:16:36.884+00:00I just went to work at the Starbucks next door on ...I just went to work at the Starbucks next door on my paper, with a cup of latte I like most. This does not mean that I am working to make a living at the starbuck. Do I mean to let you know I am a staff working for the starbuck? Come on, guys, even if you are working at the starbuck with 2 phds, it does not mean that there is anything to be irrespectful for a guy to make a living at the starbuck Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-70376353223869370832011-11-08T12:34:55.164+00:002011-11-08T12:34:55.164+00:00When Benitec's fortunes go tearing straight pa...When Benitec's fortunes go tearing straight past Alny in <br />the not so distant future, now that the ddRNAi patents are all secured in the U.S, Europe and Asia, we'll gladly have Dirk on board the management team. Coffee, Aussie dollar remuneration & Qantas flights thrown in as a bonus.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-50548557614511313452011-11-08T06:29:03.216+00:002011-11-08T06:29:03.216+00:00HaHaHaHa!!! That's exactly what I thought when...HaHaHaHa!!! That's exactly what I thought when I read it too. I nearly choked on my cornflakes. Not that there's anything wrong with working at Starbucks. So many Phd's working there now, I hear it has become a job requirement.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-63478332056210620702011-11-08T04:30:59.198+00:002011-11-08T04:30:59.198+00:00I thought with your qualifications you could get a...I thought with your qualifications you could get a better job than working at Starbucks!Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-91446785294706132102011-11-08T02:16:22.729+00:002011-11-08T02:16:22.729+00:00"MicroRNA Therapeutics seems to have found it..."MicroRNA Therapeutics seems to have found its poster child already with Santaris’ miR122 LNA antagonist for the treatment of HCV"<br /><br />Poster child with a paternity law suit.tettrazininoreply@blogger.com