tag:blogger.com,1999:blog-7857054149675424609.post6387943270642308868..comments2024-02-24T08:58:08.581+00:00Comments on RNAi Therapeutics: Voyager Therapeutics Sets Out to Fulfill Promise of AAV-directed RNAi Therapeutics (and More)Dirk Hausseckerhttp://www.blogger.com/profile/18320439857875629714noreply@blogger.comBlogger38125tag:blogger.com,1999:blog-7857054149675424609.post-22019372699270294042014-11-19T02:21:42.872+00:002014-11-19T02:21:42.872+00:00What do you make of Benitec's agreement with T...What do you make of Benitec's agreement with Touchlight? You have called for Benitec to have its own lab and now it has. Do you see the doggybone technology as being a useful tool in the development of ddRNAi in the way that you have advocated in this blog?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-34760155610925527952014-09-05T05:59:43.658+00:002014-09-05T05:59:43.658+00:00Sure hope you have FTO from Benitec to go ahead an...Sure hope you have FTO from Benitec to go ahead and make all these appointments. lol<br /><br />But more interesting is what it is you are using to get across the BBB.<br /><br />Brave enough to post a piece on your blog about that?<br /><br />From Voyager's website:<br /><br />Voyager Therapeutics is developing life-changing gene therapies for fatal and debilitating diseases of the central Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-8646890884995388582014-08-12T00:50:35.518+00:002014-08-12T00:50:35.518+00:00From today's NYTimes (features Voyager Therape...From today's NYTimes (features Voyager Therapeutics within the article): <br /><br />http://tinyurl.com/ofr79vp<br /><br />Gene Strategy to Fight Alzheimer’s Clears a Hurdle<br /><br />By PAM BELLUCK<br />August 11, 2014 5:19 pm<br /><br />Excerpt:<br /><br />Dr. Steven Paul, a professor of neuroscience at Weill Cornell Medical College, has found that by using gene therapy to implant mice Latebloomerhttps://www.blogger.com/profile/13836422758275477595noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-6053821769385533572014-06-09T08:11:03.849+00:002014-06-09T08:11:03.849+00:00Is Voyager any closer to achieving the following? ...Is Voyager any closer to achieving the following? Would give it commercial credibility of they were. Noteworthy too, is CSL, $34bn worth of company, has initiated the same type of ADR with the same sponsor for themselves. They go live tomorrow. Perhaps there are others from Australia doing same.<br />Oddly however, there are still no quotes for the said code.<br /><br />SYDNEY, May 30, 2014 /Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-8059773073181694642014-04-01T17:11:08.942+00:002014-04-01T17:11:08.942+00:00CoH option expired. BLTO about to in a week. If th...CoH option expired. BLTO about to in a week. If their execs weren't so busy self promoting in the media they would've had time to comply with listing requirements and suspend trading in them.<br />Just another clumsy piece of non-management from management.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-75668882037148614602014-04-01T01:09:42.740+00:002014-04-01T01:09:42.740+00:00CoH HIV Option Expired
If you don't believe m...CoH HIV Option Expired<br /><br />If you don't believe me, simply ring the company and ask them. Then you can post an apology on this thread.<br />Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-90335074499104751302014-03-31T22:15:29.320+00:002014-03-31T22:15:29.320+00:00How would you know the CoH patent options expired ...How would you know the CoH patent options expired as the terms were undisclosed? Making it all up like the last poster's tangential prose I think.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-54356080137392091232014-03-31T21:12:45.314+00:002014-03-31T21:12:45.314+00:00According to BLT puff videoes, they have a lab wit...According to BLT puff videoes, they have a lab with beaker carrying eye candy for staff. No wonder they fired Monsoon and Rudi.<br /><br />Dirk is completely right. Australian biotech is a weeping wound devoid of any credibility. BLT being the most notable. At least other failures were able to get into trials. Of their HCV trial ever does start it will finish the way PRAN did overnight.<br /><br Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-62738764012138702332014-03-31T15:37:14.968+00:002014-03-31T15:37:14.968+00:00" is they have licence options on this progra..." is they have licence options on this programs CoH HIV patents which go well into the 2020's"<br /><br />Actually, Benitec does not have the option to license these patents. The option has lapsed and CoH is now free to license to whoever else they like.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-91972984865363694552014-03-31T13:54:17.539+00:002014-03-31T13:54:17.539+00:00After Calimmune getting more CIRM funding for thei...After Calimmune getting more CIRM funding for their BLT licenced ddRNAi HIV moon shot, yet more money, smarter than the smartest individual biotech brain, is going into City of Hope's ddRNAi HIV moonshots (plural - 3 ways to deliver to the masses).<br /><br />Nice thing for Benitec, who can start looking to open a lab now they are also well funded, is they have licence options on this Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-28561363132048480032014-02-18T00:56:30.009+00:002014-02-18T00:56:30.009+00:00May be the University of Westminster knows more ab...May be the University of Westminster knows more about Benitec's TT-034 than some of the the commentators on this blog. <br /><br />http://www.westminster.ac.uk/news-and-events/news/science-and-technology/2014/university-of-westminster-develops-groundbreaking-method-to-test-hepatitis-c-cureAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-65994973419956023132014-02-17T09:21:56.630+00:002014-02-17T09:21:56.630+00:00Dirk, are you aware of VLA and their coxsakie viru...Dirk, are you aware of VLA and their coxsakie virus for delivery viz the AAV?<br />Does this shift with Voyager mean you don't rate it if you are?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-6438162567393798452014-02-16T05:46:16.013+00:002014-02-16T05:46:16.013+00:00I retract the statement about dying of cancer as v...I retract the statement about dying of cancer as very foolish. Both men should be applauded for their work and contributions to a dignified and necessary art. Sorry.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-44995769436825708042014-02-16T03:32:21.127+00:002014-02-16T03:32:21.127+00:00There is no doubt that this post has stirred up a ...There is no doubt that this post has stirred up a lot feeling about Voyager using ddRNAi and Benitec's position. However, Dirk is entitled to his opinion and, in fairness to him, he has retained all the comments which disagree with his position, so I don't think we could reasonably expect more than that.<br /><br />On the BLT positive side, IF Voyager do not intend to take a licence from Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-79111499583073210802014-02-16T00:55:48.435+00:002014-02-16T00:55:48.435+00:00Who cares where his bias is.. Im just grateful som...Who cares where his bias is.. Im just grateful someone is summarizing this field for those of us whom wish to follow this but not through FDA filings.<br /><br />At the end of the day its up to each of us to decide how we wish to invest and with whom. The final tally will come when the science is proven.. <br /><br />If your pining for Benitec and Dirks bashing them you should be glad your Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-15626307814918420502014-02-15T23:48:28.525+00:002014-02-15T23:48:28.525+00:00So the whole future in cancer research and 'th...So the whole future in cancer research and 'the new science' revolves about dirk/ kay?<br />Hope both die broke of cancer.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-61980381863071611842014-02-15T22:21:42.584+00:002014-02-15T22:21:42.584+00:00Sounds like a Cramer trick.
Depending on who he i...Sounds like a Cramer trick.<br /><br />Depending on who he is contracted to the SEC might find some fertile ground here.<br /><br />Which could provide a reason as to why he was fired.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-9961082134808643672014-02-15T21:50:45.656+00:002014-02-15T21:50:45.656+00:00Agree completely on the bad karma between the prin...Agree completely on the bad karma between the principals.<br /><br />Answer this: Dirk buys quietly, he says, with his own money 1.5% or more of Marina Biotech. He then gives them a big verbal pump on the blog without explaining, in depth, the underlying value and tech of Marina. It was a very cursory explantion for an investment that size.<br /><br />Since Dirk purchased 1.5 % of all shares at Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-55451543448762847362014-02-15T19:44:08.529+00:002014-02-15T19:44:08.529+00:00That's a bit rich. Dirk should delete that one...That's a bit rich. Dirk should delete that one as its based on nothing but the authors own bias.<br />I prefer to think of Dirk n Kays enmity for BLT being rooted in a much more personal level.<br />Dirk because he was fired by them and La Jolla.<br />Kay because of the Avocell history and his failed relationship with the CEO. Who ended up in Tacere. Now holds equity in BLT. Kay wants his Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-90989865179943731232014-02-15T19:12:12.433+00:002014-02-15T19:12:12.433+00:00THIS IS NOT FULL DISCLOSURE!
Full disclosure: I&#...THIS IS NOT FULL DISCLOSURE!<br /><br />Full disclosure: I'm a freelance RNAi Therapeutics analyst and consultant.<br /><br />Dirk was to lazy to more then cut and paste from the blog.<br /><br />Freelance and consultant means hired hand to anyone who wants to pay his price.<br /><br />This can mean: Other Pharma that wants the Benitec technolgy to fail, or stock boiler rooms that want to Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-39042265640541015642014-02-14T20:08:31.163+00:002014-02-14T20:08:31.163+00:00Er, folks? Nice argument about who's got the l...Er, folks? Nice argument about who's got the longest schlong and all, but am I the only one to be popping my eyeballs on the results that a 5 bp mismatch on the seed can still give on-target RNAi with an siRNA? Is it me or are these data putting into question how we think RNAi mediators pick their targets? Mac Bioinformatics noobhttps://www.blogger.com/profile/07063101439530299729noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-78317422337486126332014-02-14T19:50:37.934+00:002014-02-14T19:50:37.934+00:00Seems like a lot of people have seen right through...Seems like a lot of people have seen right through this crappy blog post Dirk- I for one am not surprised as your affiliations (stock investments?) have been obvious for years. Are you selling your RNAi investment guide at AsiaTIDEs? I would be careful about what I say on the podium there, that ex-Pfizer author will be presenting this paper in Tokyo too and I hear he takes no prisoners with Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-17601895646576626762014-02-14T14:39:56.016+00:002014-02-14T14:39:56.016+00:00Calimmune already have a licence with Benitec, and...Calimmune already have a licence with Benitec, and their HIV trial is already dosing patients. Uniqure also have a licence with Benitec, for Huntington's disease.<br /><br />Splitting hairs I know. <br /><br />Can we can assume Voyager don't plan on commercialising anything until the next decade,<br />seeing as they figure a licence from Benitec won't be required?<br /><br />Are they Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-42459110180245769172014-02-14T14:05:29.077+00:002014-02-14T14:05:29.077+00:00The Baulcombe reference as being the real gatekeep...The Baulcombe reference as being the real gatekeeper is plain wrong. <br /><br />Its IP claim acknowledges the prior art included Graham, and their invention only applies after Graham. <br /><br />Slightly important because it would not have been allowed otherwise, had it claimed Graham invention. <br /><br /> Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-13291257822657708562014-02-14T12:30:04.352+00:002014-02-14T12:30:04.352+00:00This is the problem with Australians.Is Ross still...This is the problem with Australians.Is Ross still involved?Anonymousnoreply@blogger.com