tag:blogger.com,1999:blog-7857054149675424609.post7236409435365325569..comments2024-02-24T08:58:08.581+00:00Comments on RNAi Therapeutics: Tekmira Tells Alnylam ‘Enough is Enough’Dirk Hausseckerhttp://www.blogger.com/profile/18320439857875629714noreply@blogger.comBlogger21125tag:blogger.com,1999:blog-7857054149675424609.post-32745288479718474062011-03-28T05:31:38.557+00:002011-03-28T05:31:38.557+00:00Another major RNAi player sued for infringement , ...Another major RNAi player sued for infringement , and this act although justified set that company back years and almost sent it insolvent , today with the US and other patents reissued the company now has the strongest and most tested IP position in the RNAi space , I doubt however that the company would ever litigate again , except as a very last resort. Tekmira has put itself in such a Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-79219768360776188582011-03-26T20:03:33.548+00:002011-03-26T20:03:33.548+00:00"Have you seen the actual agreements on paten..."Have you seen the actual agreements on patents?"<br /><br />The patent offices determine the rules of patenting, not company agreements. This case is also not about changing the agreement on the circumstances under which Tekmira or Alnylam have access to SNALP-related IP, but whether Alnylam engaged in abusive behavior to misappropriate SNALP IP and know-how and undermine Tekmira'sDirk Hausseckerhttps://www.blogger.com/profile/18320439857875629714noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-74135537074942959402011-03-26T19:42:32.658+00:002011-03-26T19:42:32.658+00:00Dirk,
You seem to be very pro-TKM. Are you/were y...Dirk,<br /><br />You seem to be very pro-TKM. Are you/were you a consultant for them? Have you seen the actual agreements on patents?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-31145077605779106792011-03-24T04:47:31.533+00:002011-03-24T04:47:31.533+00:00The standstill between Alnylam and Tekmira expires...The standstill between Alnylam and Tekmira expires on January 8 of 2012. But there are many circumstances where this standstill becomes ineffective: <br />Tekmira in talks with another party on strategic transaction (e.g. Merck, Novartis);<br />both companies thinking that it is in the best interest of all to merge now etcDirk Hausseckerhttps://www.blogger.com/profile/18320439857875629714noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-19618391444187700132011-03-23T13:31:31.332+00:002011-03-23T13:31:31.332+00:00Dirk
Do you know if there is a standstill agreeme...Dirk<br /><br />Do you know if there is a standstill agreement that prevents ALNY from trying to buy TKM???Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-8591672527456622052011-03-19T01:44:26.715+00:002011-03-19T01:44:26.715+00:00Litigation is always a last resort option in comme...Litigation is always a last resort option in commerce. When it does happen the rule of thumb is the plaintiff nearly always has a genuine case and always ends up the loser. Any win being pyrrhic in nature.<br /><br />Anyone who is long on TKM. Good luck.<br /><br />ALNY will be bought out I am guessing and then TKM will probably be picking a fight with PFE.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-23224564096439651362011-03-18T23:19:04.485+00:002011-03-18T23:19:04.485+00:00For those that think TKM has a litigious MO bear i...For those that think TKM has a litigious MO bear in mind that the two previous lawsuits they were involved with were actually lawsuit actions launched by the other side: 1. Sirna (Merck) and 2. the previous Tekmira (Inex) Mnmt who were replaced by the Mnmt from Protiva upon their merger and settlement of their lawsuit. There are many similiar "theft of IP" issues with this ALNY lawsuit Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-12096019492445711872011-03-18T15:26:21.623+00:002011-03-18T15:26:21.623+00:00I read the complaint from the TKM website..If I wa...I read the complaint from the TKM website..If I was a betting man I would say TKM has a whilstle blower from ALNY giving them data an mot likely hard data like memorandums....<br /><br />TKM keeps saying they are informed. I think as a practical matter they may be well informed and that is not good for ALNY.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-17181724057141738182011-03-18T15:06:17.037+00:002011-03-18T15:06:17.037+00:00While I am pessimistic on the role of big pharma a...While I am pessimistic on the role of big pharma and the wide-spread commercial success of RNAi (at least for the next 5 yrs), I don't believe the technology is dead and there isn't hope for its future success. It may be like MAB's 2.0, as many have compared the historical parallels in the development cycle. We're currently in the "valley of death" cycle of technology Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-75900795903254377542011-03-18T14:11:44.085+00:002011-03-18T14:11:44.085+00:00"I believe this lawsuit will cause irreparabl..."I believe this lawsuit will cause irreparable damage to Tekmira, and perhaps Alnylam too, and the RNAi field as a whole. It mostly damages Tekmira as their litigious M.O. is clearly indoctrinated as a cultural aspect of their company DNA and is now sure to turn away potential partners."<br /><br />There is a general good point here I believe in that partnerships in which roles are not Dirk Hausseckerhttps://www.blogger.com/profile/18320439857875629714noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-75715114467678234312011-03-18T14:02:02.706+00:002011-03-18T14:02:02.706+00:00Quite interesting discussion..you can tell who is ...Quite interesting discussion..you can tell who is long ALNY or TKM.<br /><br />But what I want to know is are there any employees of either enetity posting here?<br /><br />Opinions are easy, and do not cost anything.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-76526544938210472062011-03-18T11:35:54.191+00:002011-03-18T11:35:54.191+00:00...which has already proven safe in humans...which has already proven safe in humansAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-59007464839712255602011-03-18T11:34:39.030+00:002011-03-18T11:34:39.030+00:00then how come City of Hope are proceeding with nex...then how come City of Hope are proceeding with next stage in the expressed RNAi HIV Stem cell trial??Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-74776500216157390612011-03-18T02:19:54.734+00:002011-03-18T02:19:54.734+00:00I don't agree with the premise that the big-ph...I don't agree with the premise that the big-pharma players are pulling out just to focus on near term projects. They should have known that developing an RNA based therapy would be a long and difficult road.<br /><br />I don't see Roche walking away from a half-billion dollar investment because of short term focus. Same for Pfizer, why do they shut down a 100 person OTU division, after Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-80746116361958976982011-03-18T01:39:51.241+00:002011-03-18T01:39:51.241+00:00How would it look to a jury if the primary financi...How would it look to a jury if the primary financial backing for the lawsuit came from ALNY's main competition? I think people need to back away from buyout fantasies and conspiracy theories and just take a deep breath. Hopefully this all gets resolved amicably soon (or as amicably as possible given the circumstances). The whole RNAi space is struggling enough as it is without a protracted sherknoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-58632903484152181852011-03-18T01:25:48.314+00:002011-03-18T01:25:48.314+00:00I can't help but weigh in...
First some conte...I can't help but weigh in...<br /><br />First some context...<br /><br />- Big Pharma pulls back from siRNA to focus on near-term projects that can have an impact on the bottom-line in the next quarters or couple of years<br /><br />- ALNY and Merck settle - recall that Merck's $1 billion investment in Sirna was at stake. If Merck lost the suit, they'd lose $1 billion.<br /><br />- Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-13165093341394918082011-03-18T00:27:53.480+00:002011-03-18T00:27:53.480+00:00I believe this lawsuit will cause irreparable dama...I believe this lawsuit will cause irreparable damage to Tekmira, and perhaps Alnylam too, and the RNAi field as a whole. It mostly damages Tekmira as their litigious M.O. is clearly indoctrinated as a cultural aspect of their company DNA and is now sure to turn away potential partners.<br /><br />As bad as things are currently in the field, this action only furthers the demise as these petty Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-26470739768878212302011-03-17T19:50:05.103+00:002011-03-17T19:50:05.103+00:00Your blog clearly suggests how ill-informed you ar...Your blog clearly suggests how ill-informed you are about TKM claims and their attitute when it comes to their bussiness of bullying to get money. When they clearly realised ALNY no longer need them for LNP Delivery they want to get money some other way. After merging with TKM Protiva got rid of their original founders and now they are claiming the founders' brain belong to them for ever. Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-5260220440526929502011-03-17T15:14:31.424+00:002011-03-17T15:14:31.424+00:00Dirk
The sad part is,,ANLY could have issued 10MM...Dirk<br /><br />The sad part is,,ANLY could have issued 10MM shares and bought TKM for chump change. Now my legal mind says the well is poisoned and TKM has no use for the people at ALNY. Sad.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-60212636748199355612011-03-17T14:06:40.538+00:002011-03-17T14:06:40.538+00:00That elusive white knight has been a long time com...That elusive white knight has been a long time coming. Furthermore, it's likely Tekmira resorted to this lawsuit after failing to close any collaborations on its own - don't expect any deals to happen until after the lawsuit is resolved.sherknoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-52262246445332124332011-03-17T12:20:35.997+00:002011-03-17T12:20:35.997+00:00ALNY and its CEO and Board has seen fit to destroy...ALNY and its CEO and Board has seen fit to destroy market cap in wave after wave of arrogant behavior. Tekmira's suit and your analysis points out again that ALNY and their management are not to be trusted. It should have been obvious by the years of deal promises and the high compensation they received. <br /><br />It would not surprise me in here if TKM gets a white knight via a Anonymousnoreply@blogger.com