tag:blogger.com,1999:blog-7857054149675424609.post787527517755991503..comments2024-02-24T08:58:08.581+00:00Comments on RNAi Therapeutics: Big Pharma Panic over Nucleic Acid Therapeutics Dirk Hausseckerhttp://www.blogger.com/profile/18320439857875629714noreply@blogger.comBlogger35125tag:blogger.com,1999:blog-7857054149675424609.post-9206977058991601292015-07-07T01:04:31.791+00:002015-07-07T01:04:31.791+00:00Dirk quit writing just when things are getting bri...Dirk quit writing just when things are getting bright. . . I wonder how much he is buying before the ipo.Anonymoushttps://www.blogger.com/profile/06438406102747733290noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-53425774508953398282015-07-07T01:00:56.665+00:002015-07-07T01:00:56.665+00:00Fiscal year tax saleFiscal year tax saleAnonymoushttps://www.blogger.com/profile/06438406102747733290noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-965037824366396332015-07-03T09:24:47.660+00:002015-07-03T09:24:47.660+00:00would suggest anyone thinking ra reducing holdings...would suggest anyone thinking ra reducing holdings on the surface is a bad sign for the future of benitec to stop investing. if you had been watching the stock movements closely for some time now you would clearly see this is an attempt to draw more shares from previous holders. give it a couple of months, you will see what i mean. Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-1124291291522548732015-07-03T07:05:14.226+00:002015-07-03T07:05:14.226+00:00You may have a point there. RA Capital's Kolch...You may have a point there. RA Capital's Kolchinsky is selling down their holding with another million gone. Why would he be doing that just ahead of an IPO?<br /><br />Maybe the IPO will never see the light of day. CEO will have to dream of big houses on the waterfront.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-17451807301184959542015-06-30T21:22:03.628+00:002015-06-30T21:22:03.628+00:00Benitec is using old technology. Wonder how much s...Benitec is using old technology. Wonder how much screwing with the promoter to circumvent toxicity contributed to the heterogeneity of transcription initiation that they observed? Garbage was indeed produced at the end of the day, not something to tout or be proud of, beyond them doing due diligence.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-24338993474192210832015-05-25T20:07:31.158+00:002015-05-25T20:07:31.158+00:00Ladies and gentlemen: your attention please. Dirk,...Ladies and gentlemen: your attention please. Dirk, has finally decided to stop downsiding benitec. . . and . . . the anonymous accuser continues to be annonymous. Anonymoushttps://www.blogger.com/profile/06438406102747733290noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-73462971206775749672015-04-09T01:25:03.963+00:002015-04-09T01:25:03.963+00:00Note:
Not a random bout of emotion.Note:<br /><br />Not a random bout of emotion.Anonymoushttps://www.blogger.com/profile/06438406102747733290noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-44342455289656024002015-04-09T01:23:39.415+00:002015-04-09T01:23:39.415+00:00This comment has been removed by the author.Anonymoushttps://www.blogger.com/profile/06438406102747733290noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-43940426639227135412015-04-09T01:22:49.216+00:002015-04-09T01:22:49.216+00:00Are you working with Benitec to make use of Lk03?Are you working with Benitec to make use of Lk03?Anonymoushttps://www.blogger.com/profile/06438406102747733290noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-32982457390564074972015-04-08T23:49:48.608+00:002015-04-08T23:49:48.608+00:00Next article should be:
TRANSDUCTION PROVEN WITH ...Next article should be:<br /><br />TRANSDUCTION PROVEN WITH 1 PERCENT OF THERAPEUTIC DOSE<br /><br />again, not anonymous.Anonymoushttps://www.blogger.com/profile/06438406102747733290noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-7484902320280903642015-04-08T23:36:48.909+00:002015-04-08T23:36:48.909+00:00I'm not anonymous. . . after Dirk's tweet...I'm not anonymous. . . after Dirk's tweets and Micheal Murphys report, the stock goes up. No blame or complaints, here. Whatever these guys are saying, keep it up.Anonymoushttps://www.blogger.com/profile/06438406102747733290noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-24145268254570974842015-04-07T11:37:47.980+00:002015-04-07T11:37:47.980+00:00Benitec announcement of confirmed shRNA transducti...Benitec announcement of confirmed shRNA transduction actually very encouraging! Dirk's tweets on the other hand say, well, nothing really from what I can tell. <br /><br />Righto, back in my hole. Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-15623286922642330072015-04-07T08:42:19.208+00:002015-04-07T08:42:19.208+00:00Anyone see the BLT tweets from Dirk?
Most unusua...Anyone see the BLT tweets from Dirk? <br /><br />Most unusual for the vigilantes to still be in their holes.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-64063545277145079282015-04-05T20:27:52.272+00:002015-04-05T20:27:52.272+00:00Man! What is it with these anonymous Benitec suppo...Man! What is it with these anonymous Benitec supporters who blame Dirk for all its failings? <br /><br />I guess the leadership from shareholders and executive have got nothing to do with it. It's all Dirk's fault.<br /><br />First rule of investing: don't fall in love with a stock.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-74444575617442227792015-04-05T18:30:09.923+00:002015-04-05T18:30:09.923+00:00I expect more of you, Dirk. . Too All: Please read...I expect more of you, Dirk. . Too All: Please read benitec's ceo update from Jan 2014. While Kay researches how to make a better mousetrap, let's cure some human patients sooner. . . . .and with Kay's improved science, cure some more later. . . AAV8 today . . . Version LK03. . . tomorrow. . . Free advice would be harmless. . . Unfortunately your monologue is not helping patients get Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-75432885831526854052015-04-05T16:14:45.293+00:002015-04-05T16:14:45.293+00:00Also, what you call "garbage", I call th...Also, what you call "garbage", I call the lasting and beneficial production of an intracellular "vaccine" that has the ability to stop reinfection. . . Now, today. . . Will insurance companies pay for a second or third "cure". . . Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-13579665868070334502015-04-05T15:56:12.145+00:002015-04-05T15:56:12.145+00:00There will always be a 2.0 version, 2.1, 2.2 . . ....There will always be a 2.0 version, 2.1, 2.2 . . . Ok. While that ddrnai 2025 10.0 version is being developed on paper or in a lab, the real life story is live and in person, treating patients, right now. . . Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-19190888401729966612014-02-10T13:09:23.631+00:002014-02-10T13:09:23.631+00:00As it's been proven safe and effective in mice...As it's been proven safe and effective in mice and NHP's, and the FDA has agreed for the trial start, maybe Benitec are actually pretty smart on getting on with this therapeutic in the clinic. They will soon have more learnings than all the mice and NHP studies will ever give them. <br />And if they can improve their ddRNA expression cassette design even more then great, a potentially Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-63220604969782617902014-02-10T10:11:33.120+00:002014-02-10T10:11:33.120+00:00The paper is the best support for what I've be...The paper is the best support for what I've been saying for the last several years regarding Benitec: the company has failed to further develop its technology. This is because the paper shows that their expression cassettes generate a lot of 'garbage' RNAs as researchers in the field (including work by the Kay lab and Shuo Gu) have shown how to design more cleanly processed ddRNA Dirk Hausseckerhttps://www.blogger.com/profile/18320439857875629714noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-33530400903882350772014-02-09T06:44:03.129+00:002014-02-09T06:44:03.129+00:00This paper newly published in Nature by Tacere / P...This paper newly published in Nature by Tacere / Pfizer researchers of interest to those invested in, or considering investment in, Benitec. Importantly, it's very material to the TT-034 clinical trial itself. <br /><br />Knockers will knock but this is an absolute game changer if the trial results come out solid. <br /><br />http://www.nature.com/mtna/journal/v3/n2/full/mtna201373a.htmlAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-76530888081231738502014-01-14T12:41:48.692+00:002014-01-14T12:41:48.692+00:00The FDA has just approved an HCV RNAi gene therapy...The FDA has just approved an HCV RNAi gene therapy clinical trial.<br /><br />http://uk.reuters.com/business/quotes/BLT.AX/key-developments/article/2902773<br /><br /> Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-57002606137302807022014-01-13T03:50:47.075+00:002014-01-13T03:50:47.075+00:00I'm sometimes thrown by the seemingly random b...I'm sometimes thrown by the seemingly random bouts of emotion that run through the gamut of responses/accusations in the comment sections of Dirk's articles. <br /><br /><br />"Yet Dirk buys at least 1.5% of Marina Biotech and stands on the back of the wagon and trumpets it to the throngs. Now he accuses you investors of imprudent investment behavior. Now would any of you have bionoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-26344250541100808992014-01-12T08:51:24.710+00:002014-01-12T08:51:24.710+00:00Mark Kay asked me to post this in response to some...Mark Kay asked me to post this in response to some of the comments made here:<br /><br />I would like to make a few statements in response to some of the comments about the paper we published in Nature. I was one of the senior investigators on the first clinical trial in which AAV was administered systemically in a human. This was AAV-2 vector expressing human factor IX. Although there was Dirk Hausseckerhttps://www.blogger.com/profile/18320439857875629714noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-73152008554668414582014-01-11T22:49:45.891+00:002014-01-11T22:49:45.891+00:00Yet Dirk buys at least 1.5% of Marina Biotech and ...Yet Dirk buys at least 1.5% of Marina Biotech and stands on the back of the wagon and trumpets it to the throngs. Now he accuses you investors of imprudent investment behavior. Now would any of you have purchased Marina an almost bankrupt company with what proven tech? Talk about the pot calling the kettle black. Also Dirk do you have any connection with the Marina team past or present? Your Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-24372036515995401252014-01-11T21:39:51.481+00:002014-01-11T21:39:51.481+00:00Murine models are often very helpful when it comes...Murine models are often very helpful when it comes to proof of concept, but can often fall down when attempts are made to replicate positive findings in mice/rats/guinea pigs/rabbits etc in non human primate models. Tacere has done the hard yards in NHP and claim very favourable results with AAV8, so why believe a rehash of the previous work done in mice in preference to those NHP studies?<br /><Anonymousnoreply@blogger.com