tag:blogger.com,1999:blog-7857054149675424609.post9092592606123893099..comments2024-02-24T08:58:08.581+00:00Comments on RNAi Therapeutics: The GalNAc WarsDirk Hausseckerhttp://www.blogger.com/profile/18320439857875629714noreply@blogger.comBlogger8125tag:blogger.com,1999:blog-7857054149675424609.post-23169689598732387922014-06-05T09:53:37.530+00:002014-06-05T09:53:37.530+00:00Dirk, could you please write a blog on ARWRs new d...Dirk, could you please write a blog on ARWRs new delivery 2.0 and if subq is imminent? Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-47603080915612572852014-06-04T22:01:02.188+00:002014-06-04T22:01:02.188+00:00For those interested into the structure and synthe...For those interested into the structure and synthesis of "Alnylam's" tridentate GalNAc ligand please have a look to this paper from dutch colleagues (from 1999): <br />http://www.ncbi.nlm.nih.gov/pubmed/10052968<br />Does someone knows an older paper and/or patent regarding this TRIS-based ligand? <br />Alnylam's oligo coupling chemistry especially with respect to the solid Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-90714976587483277622014-06-04T18:09:56.259+00:002014-06-04T18:09:56.259+00:00Thanks for the Regulus clarification. I'm won...Thanks for the Regulus clarification. I'm wondering though to what degree, if at all, Alnylam is assisting them to realize it.<br /><br />Regarding ISIS and why they haven't employed GalNAc yet? Good question. I'm actually been wondering why they have not done too much in terms of adding chemistries to their oligos for enhancing delivery and making it more specific in general. It&#Dirk Hausseckerhttps://www.blogger.com/profile/18320439857875629714noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-40410855215073645732014-06-03T13:03:38.092+00:002014-06-03T13:03:38.092+00:00Dirk, Regulus isn't actually paying any licens...Dirk, Regulus isn't actually paying any license fees - their arrangement with Alnylam lets them use ALNY's GalNAc platform freely for miRNAs (per the CEO/CSO).<br /><br />One question I have, though, is that if GalNAc conjugation has been known for so long and is apparently pretty effective, why hasn't Isis gotten it work before now? They've been around a lot longer than Alnylam.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-15059833698105206622014-06-03T08:09:24.279+00:002014-06-03T08:09:24.279+00:00I believe we are on the same page regarding GalNAc...I believe we are on the same page regarding GalNAc per se: a free-for-all. However, even Regulus referred to their Alnylam license when it disclosed it was using GalNAc for its miR122 program. Why mention it and pay license fees when it does not have to?<br /><br />I'm pretty sure that while the exact realization can well be chemically unique in each case, the fundamental strategies can Dirk Hausseckerhttps://www.blogger.com/profile/18320439857875629714noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-69163437985687504922014-06-03T04:36:54.274+00:002014-06-03T04:36:54.274+00:00Dirk, there is no IP conflict here. GalNAc as a d...Dirk, there is no IP conflict here. GalNAc as a delivery enhancer predates Alnylam or Isis. The earliest commercial GalNAc IP for oligos was patented by Alnylam's Mano Manoharan...while he was at Isis. Both Isis and Alnylam (and Regulus, and Santaris) have freedom to operate. Any IP revolves around the method for linking the GalNAc to the oligo, but the methods for doing this are Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-67006591468645614322014-06-02T18:58:06.830+00:002014-06-02T18:58:06.830+00:00C'mon this is not about resolution of conflict...C'mon this is not about resolution of conflict, but market share and profit maximisation. For charity, look elsewhere.Dirk Hausseckerhttps://www.blogger.com/profile/18320439857875629714noreply@blogger.comtag:blogger.com,1999:blog-7857054149675424609.post-70652022907841827642014-06-02T18:46:29.625+00:002014-06-02T18:46:29.625+00:00Identification of a potential problem of IP confli...Identification of a potential problem of IP conflict requires the provision of a potential solution.<br />What could that be?Anonymousnoreply@blogger.com