Monday, August 31, 2015
Tuesday, June 23, 2015
This point has come for me and the RNAi Therapeutics blog and I look forward to take part in the conversation with renewed energy and ideas. Until then, you can follow the 'light' version of this blog on Twitter @RNAiAnalyst.
Thursday, June 11, 2015
Wednesday, June 10, 2015
Regardless, the GalNAc-ESC genie is out of the bottle.
Thursday, June 4, 2015
Wednesday, May 27, 2015
The news this morning that the preferred stock overhang (àTang Capital Partners) had finally been cleared, then paved the way towards the financing (amount and pricing to be determined).
Beyond the skin and eye, self-delivering RNAi strategies hold considerable promise for other tissue targets, both by direct/local and systemic delivery. In terms of local delivery, I would be highly interested in the biodistribution of intrathecally administered sd-RNAi triggers in non-human primates. This is because of their long phosphorothioated single-strand overhang and thus similarity to phosphorothioate antisense oligonucleotides which are starting to show amazing results in the clinic for CNS applications (watch out for update on the infant ISIS-SMNRx study by Isis Pharmaceuticals).
Saturday, May 16, 2015
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